ABSTRACT Nanotechnologies are an expression of the human ability to control and manipulate matter on a very small scale. Their use will enable an even and constant monitoring of human organisms, in a new and perhaps less invasive way. Debates at all levels – national, European and international – have pointed out the common difficulty of giving a complete, clear definition of nanotechnologies. This is primarily due to the variety of their components, to the fact that there is not just (...) one technology but several. The most significant medical applications of nanotechnologies are in the diagnostic and the therapeutic fields, eg biosensors and molecular imaging, providing diagnosis and drug delivery with no invasive methods involved. Like any other emerging field, such technologies imply new possibilities for improving health but, on the other hand, they are still at an experimental stage and therefore should be implemented under rigorous safety testing before going on general release. For this purpose, the ethical, legal and social implications (ELSI) of nanotechnologies have been elaborated by study groups, in order to develop solutions before the results of the tests are diffused into medical practice. The aim of this paper is to define some of the ethical issues concerning biomedical applications and to evaluate whether there is a need for new or additional guidelines and regulations. (shrink)

Classification learning is a preeminent human ability within the animal kingdom but the key mechanisms of brain networks regulating learning remain mostly elusive. Recent neuroimaging advancements have depicted human brain as a complex graph machinery where brain regions are nodes and coherent activities among them represent the functional connections. While long-term motor memories have been found to alter functional connectivity in the resting human brain, a graph topological investigation of the short-time effects of learning are still not widely investigated. For (...) instance, classification learning is known to orchestrate rapid modulation of diverse memory systems like short-term and visual working memories but how the brain functional connectome accommodates such modulations is unclear. We used publicly available repositories (openfmri.org) selecting three experiments, two focused on short-term classification learning along two consecutive runs where learning was promoted by trial-by-trial feedback errors, while a further experiment was used as supplementary control. We analyzed the functional connectivity extracted from BOLD fMRI signals, and estimated the graph information processing in the cerebral networks. The information processing capability, characterized by complex network statistics, significantly improved over runs, together with the subject classification accuracy. Instead, null-learning experiments, where feedbacks came with poor consistency, did not provoke any significant change in the functional connectivity over runs. We propose that learning induces fast modifications in the overall brain network dynamics, definitely ameliorating the short-term potential of the brain to process and integrate information, a dynamic consistently orchestrated by modulations of the functional connections among specific brain regions. (shrink)

It is an experimental fact that \ -decays produce in a cloud chamber at most one track and that this track points in a random direction. This seems to contradict the description of decay in Quantum Mechanics: according to Gamow a spherical wave is produced and moves radially according to Schrödinger’s equation. It is as if the interaction with the supersaturated vapor turned the wave into a particle. The aim of this note is to place this effect in the context (...) of Schrödinger’s Quantum Mechanics. We shall see that the properties of the initial wave function suggest the introduction of a semiclassical formalism in which the \ -wave can be described as a collection of semiclassical wavelets; each of them interacts with an atom and forms an entangled state. The interaction can be regarded as a semiclassical inelastic scattering event. The measurement selects the wave function of one of the ions, with a probability given by Born’s rule. This ion interacts with the atoms nearby leading to the formation of a droplet. One can reasonably assume that also the wavelet entangled with the selected ion has probability one to remain as part of the description of the system. The measurement process is therefore represented by a unitary operator. The wavelet remains sharply localized on a classical path \ It is still a probability wave: it determines the probability that another atom be ionized. This probability is essentially zero unless the atom lies on \ . This gives the visible track. (shrink)

Conscientious objection in the health care field—that is, refusal on the part of a medical professional to perform or cooperate in a procedure when it violates his or her conscience—is a growing concern for international legislators and a source of contentious debates among ethicists and the general public. Recognizing a general right to conscientious objection based on individual liberty, and thus a subjective right, could have negative consequences. Conscientious objection in health care settings should be fully protected, however, when the (...) objection is based on principles that are fundamental to the medical profession and the legal system. Examples from Italy and other nations show how protections there safeguard conscientious objection when a health professional objects to taking a human life. National Catholic Bioethics Quarterly 12.4 (Winter 2012): 611–620. (shrink)

A Second level Master in “Clinical Bioethics Consultation” has been organized in Italy to offer an opportunity to offer an adequate training to carry out an ethics consultation in different health fields. The master has been promoted and realized by different institutions: Catholic University of Sacred Hearth in Rome, Insubria University in Varese, “Federico II” University in Naples, Lanza Foundation in Padua and the Local Health and Social Care Unit n.7 in Veneto Region. The aim of the master is train (...) ethics consultants to offer help regarding a correct decision, which will take by others. The choice must be as much as possible shared between patient, family and health care team. Ethics consultation can be primarily request by the physicians, nurses and health care staff such as support about a choice that wants to be the most appropriate and to clarify a dilemma between different options. Secondly an ethics consultation can be demand by the patient and the family members to find a clarification about their dilemmas and future choices. Also the administrative staff could ask the consultation, when it need to better explain ad example about a specific clinical case or a question concerned the health policy. (shrink)

The contribution describes a case report addressed in 2011 by the clinical ethics consultation service team of the Institute of Bioethics and Medical Humanities at the “Agostino Gemelli” School of Medicine of the Università Cattolica del Sacro Cuore, Rome. The clinical case regards ethical dilemmas about the patient’s prospects for receiving an orthotopic liver transplant, because she was a non-resident and lacked a caregiver to assist her during the follow-up period, as well as a place to stay after liver transplant (...) surgery. DOI: 10.5294/pebi.2016.20.1.7. (shrink)

The authors report the first Italian experience of a research ethics committee (REC) audit focused on the evaluation of the REC’s compliance with standard operating procedures, requirements in insurance coverage, informed consent, protection of privacy and confidentiality, predictable risks/harms, selection of subjects, withdrawal criteria and other issues, such as advertisement details and justification of placebo. The internal audit was conducted over a two-year period (March 2009–February 2011) divided into quarters to better value the influence of the new insurance coverage regulation (...) that came into effect in March 2010 (Ministerial Decree of 14 July, 2009) and expand the requirements to safeguard participants in clinical drug trials including other critical items as information and consent and the risks to benefits ratio. Out of a total of 639 REC’s opinions and research studies, 316 were reviewed. Regarding the insurance policy requirements, Auditor/REC non-compliance occurred only in one case. The highest number of Auditor/REC non-compliance was in regard to information and consent, which should have incurred a suspended decision rather than a favorable opinion. This internal audit shows the importance and the difficulty of the review process. For this reason, specific courses for members of the research ethics committee and for those who aspire to become auditors will be provided. There may also be efforts to improve the standard operating procedures already in place. (shrink)

A rich collection of critical essays, authored by philosophers and practicing artists, examining Deleuze and Guattari's engagement with a broad range of art forms.

In his famous 1982 paper, Allen Newell [22, 23] introduced the notion of knowledge level to indicate a level of analysis, and prediction, of the rational behavior of a cognitive arti cial agent. This analysis concerns the investigation about the availability of the agent knowledge, in order to pursue its own goals, and is based on the so-called Rationality Principle (an assumption according to which "an agent will use the knowledge it has of its environment to achieve its goals" [22, (...) p. 17]. By using the Newell's own words: "To treat a system at the knowledge level is to treat it as having some knowledge, some goals, and believing it will do whatever is within its power to attain its goals, in so far as its knowledge indicates" [22, p. 13]. In the last decades, the importance of the knowledge level has been historically and system- atically downsized by the research area in cognitive architectures (CAs), whose interests have been mainly focused on the analysis and the development of mechanisms and the processes governing human and (arti cial) cognition. The knowledge level in CAs, however, represents a crucial level of analysis for the development of such arti cial general systems and therefore deserves greater research attention [17]. In the following, we will discuss areas of broad agree- ment and outline the main problematic aspects that should be faced within a Common Model of Cognition [12]. Such aspects, departing from an analysis at the knowledge level, also clearly impact both lower (e.g. representational) and higher (e.g. social) levels. (shrink)

Antonio Caso, “La existencia como economía y como caridad” (1916). Translated with Jose G. Rodriguez Jr. as “Existence as Economy and as Charity,” in 20th Century Mexican Philosophy: Essential Readings, eds. Carlos Alberto Sánchez and Robert Eli Sanchez, Jr. (New York: Oxford University Press, 2017).

This volume offers a comprehensive guide to the extensive corpus of Jean-Luc Marion’s ideas, including a discussion of contemporary French phenomenology and critical appraisal of Marion’s ideas by leading scholars in the field. The contributors apply Marion’s thought to various fields of study, including theology, art, literature and psychology.

Le Obiezioni contro la Teoria medica di G.E. Stahl, tradotte per la prima volta in italiano, rappresentano un documento di particolare interesse storico-filosofico. Da una parte Georg Ernst Stahl (1659-1734), medico, chimico, fisico, sostenitore di una fisiologia corporea a impronta “vitalista” e dall’altra Gottfried Wilhelm Leibniz (1646-1716), genio universale della matematica e della filosofia dell’età barocca. Il fulcro della polemica riguarda la possibilità di capire se e in che misura l’organizzazione meccanica di un corpo organico sia di per se sufficiente (...) a spiegare il fenomeno della vita “biologica”, o se invece si debba postulare la presenza di princìpi vitali capaci di integrare le leggi fisiologiche che strutturano la corporeità. A dispetto della lontananza storica, o anzi forse proprio in virtù di tale lontananza, la polemica tra Leibniz e Stahl ci aiuta a decifrare le radici di uno dei refrain più abusati di tanta filosofia contemporanea, il tema cioè della ‘naturalizzazione’ della vita e dello spirito. L’idea di espungere tutti gli elementi “soprannaturali” (l’anima, gli spiriti, etc.) dal novero delle spiegazioni scientifiche non è certo un’idea novecentesca e si confronta in questo caso non solo con la sua tesi opposta, ma soprattutto con una vasta gamma di soluzioni intermedie e di varianti non riduzioniste, di cui proprio la filosofia di Leibniz è uno splendido esempio. Il volume è accompagnato da un saggio di postfazione intitolato Vita e organismo tra filosofia e medicina: le ragioni di una polemica. (shrink)

_John Dewey and Continental Philosophy_ provides a rich sampling of exchanges that could have taken place long ago between the traditions of American pragmatism and continental philosophy had the lines of communication been more open between Dewey and his European contemporaries. Since they were not, Paul Fairfield and thirteen of his colleagues seek to remedy the situation by bringing the philosophy of Dewey into conversation with several currents in continental philosophical thought, from post-Kantian idealism and the work of Friedrich Nietzsche (...) to twentieth-century phenomenology, hermeneutics, and poststructuralism. This unique volume includes discussions comparing and contrasting Dewey with the German philosophers G. W. F. Hegel, Friedrich Nietzsche, Martin Heidegger, and Hans-Georg Gadamer on such topics as phenomenology, naturalism, organicism, contextualism, and poetry. Others investigate a series of connections between Dewey and contemporary French philosophy, including the notions of subjectivity, education, and the critique of modernity in Michel Foucault; language and politics in Jacques Derrida; and the concept of experience in Gilles Deleuze. Also discussed is the question of whether we can identify traces of _Bildung_ in Dewey’s writings on education, and pragmatism’s complex relation to twentieth-century phenomenology and hermeneutics, including the problematic question of whether Heidegger was a pragmatist in any meaningful sense. Presented in intriguing pairings, these thirteen essays offer different approaches to the material that will leave readers with much to deliberate. _ John Dewey and Continental Philosophy_ demonstrates some of the many connections and opportunities for cross-traditional thinking that have long existed between Dewey and continental thought, but have been under-explored. The intersection presented here between Dewey’s pragmatism and the European traditions makes a significant contribution to continental and American philosophy and will spur new and important developments in the American philosophical debate. (shrink)

During the last decades, many cognitive architectures (CAs) have been realized adopting different assumptions about the organization and the representation of their knowledge level. Some of them (e.g. SOAR [35]) adopt a classical symbolic approach, some (e.g. LEABRA[ 48]) are based on a purely connectionist model, while others (e.g. CLARION [59]) adopt a hybrid approach combining connectionist and symbolic representational levels. Additionally, some attempts (e.g. biSOAR) trying to extend the representational capacities of CAs by integrating diagrammatical representations and reasoning are (...) also available [34]. In this paper we propose a reflection on the role that Conceptual Spaces, a framework developed by Peter G¨ardenfors [24] more than fifteen years ago, can play in the current development of the Knowledge Level in Cognitive Systems and Architectures. In particular, we claim that Conceptual Spaces offer a lingua franca that allows to unify and generalize many aspects of the symbolic, sub-symbolic and diagrammatic approaches (by overcoming some of their typical problems) and to integrate them on a common ground. In doing so we extend and detail some of the arguments explored by G¨ardenfors [23] for defending the need of a conceptual, intermediate, representation level between the symbolic and the sub-symbolic one. In particular we focus on the advantages offered by Conceptual Spaces (w.r.t. symbolic and sub-symbolic approaches) in dealing with the problem of compositionality of representations based on typicality traits. Additionally, we argue that Conceptual Spaces could offer a unifying framework for interpreting many kinds of diagrammatic and analogical representations. As a consequence, their adoption could also favor the integration of diagrammatical representation and reasoning in CAs. (shrink)

Text of 1735 and 1936 eds. of the Meditationes, with concordances, reproducedon 3 microfiches (11 x 15 cm.) in pocket.

What kind of relationship subsists between an “organism” and a “monas dominans »? In some texts, Leibniz claims that the soul « actuat » the organic body and in the late debate with Stahl he describes the « monas dominans » as a « monas actuatrix ». But how does the monas « actualize » the organic body ? and what implies the semantic of the word « agere » here used by Leibniz ? Is it also possibile to describe (...) this event in terms of « whole/part » relationship ? The aim of this paper is to sketch out the status quaestionis of the topic by discussing some of the most recent studies. More specifically to propose an interpretation of the « monas dominans » as the « nota distinguens » of the whole organism. (shrink)

El artículo presenta una reflexión sobre la manera en que en los últimos veinte años la promoción de un determinado tipo de solidaridad en Chile ha contribuido a la conformación de una gubernamentalidad liberal avanzada, necesaria para la instalación de un programa neoliberal. La reflexión se enmarca en los aportes teóricos de Michel Foucault y tiene por objeto empírico piezas de publicidad de promoción de la solidaridad emitidas en Chile entre los años 2009 y 2010, que han sido analizadas en (...) el contexto del proyecto Fondecyt 1090534. Se presentan tres tipos de resultados: (a) se describen los sectores sociales que se construyen como agentes de la solidaridad, (b) se reflexiona sobre las prácticas solidarias más promovidas y (c) se indaga en la forma en que se interpela a los sujetos a ser solidarios. (shrink)

Il concetto di organismo rappresenta uno dei fuochi centrali del pensiero di Leibniz. Interrogarsi sul significato della sua definizione significa inoltrarsi su un terreno problematico particolarmente delicato della tradizione filosofico-scientifica occidentale, dal momento che tale concetto trova proprio nella filosofia leibniziana una delle sue prime esplicitazioni teoriche. Può infatti non essere banale ricordare come il termine "organismus", assente nelle lingue classiche, faccia una delle sue prime apparizioni proprio negli scritti di Leibniz, il quale lo impiega con la piena consapevolezza di (...) chi vuole contrassegnare un costrutto teorico preciso. Ricostruire la genesi storica di tale concetto significa allora riportare alla luce la complessità di strutture teoretiche entro cui esso è stato pensato da Leibniz e, al tempo stesso, consegnare all'attenzione del dibattito contemporaneo la radicale problematicità con cui il pensiero moderno, attraverso uno dei suoi maggiori interpreti, si è interrogato sulla nozione di "vita". (shrink)